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Adv Pharmacol 76 : 1337 This paper offers a masteful synthesis of how kynurenine pathway metabolties influence glutamatergic activity through direct effects on ionotropic and metabotropic glutamate receptors, vesicular glutamate transport and indirect effects at other recognition sites

[8] The honest framing for both is that these are surrogate endpoints body weight, HbA1c, liver fat measured over trial-length horizons

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However, there is little information about -tocopherol intake in the Mexican population, which may have different dietary patterns from the U.S